MicroRNAs have been demonstrated to be abnormally expressed in tumors and associated with the development of the tumors. Our aim was to analyze the role and molecular mechanisms of tumor suppressor let-7b in the papillary thyroid carcinoma.
Book Title: Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2
Author:
Published on 2017 by
ISBN: /
Total Page:
Book Category:
Book is About: Carcinoma
Download Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 eBook
The incidence of thyroid cancer has increased significantly in the last decade, and the most frequent type of this cancer is papillary thyroid carcinoma. MicroRNAs have been demonstrated to be abnormally expressed in tumors and associated with the development of the tumors. Our aim was to analyze the role and molecular mechanisms of tumor suppressor let-7b in the papillary thyroid carcinoma. Expression of let-7b and high-mobility group A2 in papillary thyroid carcinoma tissues and cell lines was assessed using quantitative reverse transcription polymerase chain reaction and western blot analysis. To explore the role of let-7b or high-mobility group A2 in the BCPAP and TPC-1 cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell methods were used. Let-7b expression was significantly downregulated while expression of high-mobility group A2 was upregulated dramatically in papillary thyroid carcinoma tissues and cells compared with that in normal thyroid tissues and cells. In addition, overexpression of let-7b or knockdown of high-mobility group A2 inhibited cell migration and invasion compared with that of control. Besides, high-mobility group A2 was negatively regulated by let-7b in BCPAP cells. Moreover, high-mobility group A2 reintroduction reversed the anti-proliferation, anti-migration, and anti-invasion roles of let-7b. Let-7b might function as a tumor suppressor in papillary thyroid carcinoma by suppressing the expression of high-mobility group A2, and therefore might provide a promising therapeutic target for patients with papillary thyroid carcinoma.
Our website offers free Carcinoma Ebooks to download. Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 is the one of great book to have from us, a free ebooks portal, the best free ebooks download library. You can find and download free ebooks in categories. No registration is required to download free e-books. We have huge collection of Carcinoma and ebooks. Each downloadable ebook has a short review with a description. You can find over thousand of ebooks that are free to download. Get ton of books with us, the open directory for free ebooks and download links, the best place to read ebooks and search free download ebooks.Carcinoma ebooks free
download Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 ebook as PDF, EPUB, MOBI, AZW and AZW3, FB2, DJVU, LIT, RFT, IBA, LRS, LRF, and LRX.
download ebooks
There are so many ebooks about Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 that are available to have. Thinking of having Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 ebook? You are in the right place. Get the ebook Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 by: .
Book Details:
- Book was ranked at 34 by Google Books for Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2
- Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 published by since 2017 with ISBNs. The book ISBN 13 Code is and ISBN 10 Code is
- Reading Mode in Text Status is false and Reading Mode in Image Status is false
- The book has " Pages" is Printed at BOOK under Category
- Rated by Raters and have average rate at ""
- eBook written in en
- Book Preview Address: http://books.google.com/books?id=0qPTvQEACAAJ&dq=Carcinoma&hl=&cd=233&source=gbs_api
Book Preview
The Button is not working? Try The Alternative links for "Roles of MicroRNA Let-7b in Papillary Thyroid Carcinoma by Regulating HMGA2 by: ":
- Server 2: SECURE LINK