The thrust of the work that has been done for this reporting period, is that elastin has the capacity to induce the growth of breast carcinoma cells which express galectin-3.
Book Title: The Role of Galectin-3 in the Interactions Between Breast Carcinoma Cells and Elastin
Author:
Published on 2002 by
ISBN: /
Total Page: 24
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Book is About: Carcinoma
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The thrust of the work that has been done for this reporting period, is that elastin has the capacity to induce the growth of breast carcinoma cells which express galectin-3. The data suggest that elastin interacts with the cells via galectin-3 on the cell surface. Elastin was also found to be a chemoattractant for breast carcinoma cells which express galectin-3 and hence there exists an elastin-galectin-3 chemotaxis signaling pathway. Elastin and galectin-3 bind with micromolar affinities comparable to binding affinities between galectin-3 and asialofetuin or polylactosamine residues. Overall in the 3 years that I have been funded, we have clearly demonstrated that the interaction of breast carcinoma cells with elastin, is not just a coincidence but has far reaching physiological implications that require a more rigorous study. I have currently assembled a team of molecular biologist and molecular biophycists/chemists to address this important question. If we can fully understand the role of galectin-3 in the interactions between breast carcinoma cells and elastin, then we will be able to halt the growth of breast metastatic tumors in the lung.
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