We expect these efforts will facilitate the early detection of oral cancer lesion, as well as the discovery of novel potential targets for pharmacoligical intervention in this devastating disease.
Book Title: Pattern of Gene Expression in Squamous Cell Carcinoma of Head and Neck
Author:Chidchanok Leethanakul
Published on 2000 by
ISBN: 9789743470479 / 9743470476
Total Page: 278
Book Category:Gene expression
Book is About: Carcinoma
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Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common cancer in the developed world. The vast majority of these malignancies involve neoplastic lesions in the oral cavity, lip, larynx, and pharynx. The goal of this study is to help elucidate the genetic changes contributing to HNSCC, and to use this knowledge to develop molecular markers heralding malignancy. We expect these efforts will facilitate the early detection of oral cancer lesion, as well as the discovery of novel potential targets for pharmacoligical intervention in this devastating disease. The ability to investigate gene expression profiles at different stages of tumor progression in HNSCC is usually limited by the remarkable heterogeneity of these neoplastic lesions. New technological breakthroughs, such as the development of laser capture microdissection (LCM), have now provided a unique platform for gene and protein expression analysis in specific cell populations. We have recently developed LCM-based techniques to procure neoplastic and phenotypically normal cells from representative sets of HNSCCs and their matching normal tissues. Indeed, we found that the laser assisted microdissection of 5,000 cells was sufficient to extract total RNA (14.7-18.6 ng) of high integrity for the synthesis of labeled amplified cDNA probes which could then be hybridized to membranes arrayed with known human cancer-related cDNAs. By this approach, HNSCCs were compared to normal tissues, and found that cancer cells exhibit a consistent decrease in expression of differentiation markers such as cytokeratins, and an increase in the expression of a number of signal transducing and cell cycle regulatory molecules, growth and angiogenic factors, and matrix degrading proteases. Unexpectedly, most of the HNSCCs overexpress members of the wnt and notch growth and differentiation regulatory systems, thus suggesting that they may contribute to squamous cell carcinogenesis.
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