CRC is the fourth most common type of cancer in men and the third most common in women worldwide. In Egypt, it contributes 4% of all cancers.
Book Title: Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma
Author:
Published on 2017 by
ISBN: /
Total Page:
Book Category:
Book is About: Carcinoma
Download Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma eBook
Abstract : Background: Colorectal carcinoma (CRC) is the third most common type of cancer and a major cause of cancer-related morbidity and mortality in the western world. CRC is the fourth most common type of cancer in men and the third most common in women worldwide. In Egypt, it contributes 4% of all cancers. The fragile histidine triad (FHIT) gene is a tumor suppressor gene and is related to normal tissue homeostasis and apoptosis. FHIT is downregulated in various carcinomas, indicating its role in the process of tumorigenesis. Computerized image analysis (CIA) studies of colonic lesions are used for objective assessment of the concentration of positive staining within the microscopic field of interest. Materials and methods: A total of 65 formalin-fixed, paraffin-embedded colorectal adenoma and carcinoma cases were studied for the expression of FHIT protein, and a correlative study was conducted between its expression and different clinicopathological parameters. Moreover, a comparative study was performed between FHIT expression in the studied cases and their CIA. Results: FHIT expression was lower in colorectal adenomas showing high-grade dysplasia than in those with low grade. Moreover, its expression decreases in CRCs than in adenomas. Conclusion: The reduction of FHIT expression occurs with rising grade of dysplasia and malignant colorectal tumors and its low expression is associated with poor prognostic factors such as lymph node metastasis, presence of distant metastasis, vascular and perineural invasion, high grade, and advanced stages. Furthermore, the CIA technique provides a more accurate assessment of the staining patterns and helps to evaluate intensity better than when depending on subjective light microscopy alone.
Our website offers free Carcinoma Ebooks to download. Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma is the one of great book to have from us, a free ebooks portal, the best free ebooks download library. You can find and download free ebooks in categories. No registration is required to download free e-books. We have huge collection of Carcinoma and ebooks. Each downloadable ebook has a short review with a description. You can find over thousand of ebooks that are free to download. Get ton of books with us, the open directory for free ebooks and download links, the best place to read ebooks and search free download ebooks.Carcinoma ebooks free
download Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma ebook as PDF, EPUB, MOBI, AZW and AZW3, FB2, DJVU, LIT, RFT, IBA, LRS, LRF, and LRX.
download ebooks
There are so many ebooks about Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma that are available to have. Thinking of having Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma ebook? You are in the right place. Get the ebook Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma by: .
Book Details:
- Book was ranked at 21 by Google Books for Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma
- Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma published by since 2017 with ISBNs. The book ISBN 13 Code is and ISBN 10 Code is
- Reading Mode in Text Status is false and Reading Mode in Image Status is false
- The book has " Pages" is Printed at BOOK under Category
- Rated by Raters and have average rate at ""
- eBook written in en
- Book Preview Address: http://books.google.com/books?id=IC4DvgEACAAJ&dq=Carcinoma&hl=&cd=260&source=gbs_api
Book Preview
The Button is not working? Try The Alternative links for "Fragile Histidine Triad Protein Expression in Colorectal Adenoma and Carcinoma by: ":
- Server 2: SECURE LINK