The PTEN tumor suppressor, which is mutated in 40%-50% of endome- trial \u003cbr\u003e\n\u003cb\u003ecancers\u003c/b\u003e, is a negative regulator of AKT. In the present study, we examined the \u003cbr\u003e\nactivation of AKT in a panel of endometrial \u003cb\u003ecancer\u003c/b\u003e cell lines and tumor samples.
Book Title: Cell and Molecular Biology of Endometrial Carcinoma
Author:Hiroyuki Kuramoto,Masato Nishida,M. Nishida
Published on 2003-07-02 by Springer Science & Business Media
ISBN: 9784431006138 / 4431006133
Total Page: 319
Book Category:Medical
Book is About: Carcinoma Cancer
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The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting the latest work in the cell and molecular biology of endometrial carcinoma, this volume is a valuable resource for gynecologists, pathologists, and molecular biologists.
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